Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized,prospective trial
Shai Efrati, Gregori Fishlev, Yair Bechor,Olga Volkov,Jacob Bergan,Kostantin Kliakhandler,Izhak Kamiager,Nachum Gal,Mony Friedman,Eshel Ben-Jacob,Haim Golan Published Jan 2013
Background: Recovery after stroke correlates with non-active (stunned) brain regions, which may persist for years. The current study aimed to evaluate whether increasing the level of dissolved oxygen by Hyperbaric Oxygen Therapy (HBOT)could activate neuroplasticity in patients with chronic neurologic deficiencies due to stroke.
Methods and findings: A prospective,randomized, controlled trial including 74 patients (15 were excluded). All participants suffered a stroke 6-36 months prior to inclusion and had at least one motor dysfunction. After inclusion,patients were randomly assigned to "treated"or "cross" groups. Brain activity was assessed by SPECT imaging; neurologic functions were evaluated by NIHSS, ADL, and life quality.
Conclusions: The results indicate that HBOT can lead to significant neurological improvements in post stroke patients even at chronic late stages.The observed clinical improvements imply that neuroplasticity can still be activated long after damage onset in regions where there is a brain SPECT/CT (anatomy/physiology) mismatch.